![]() ![]() ![]() The test is the same regardless of the stage of Lyme disease. If you suspect you are experiencing symptoms of late-stage Lyme disease, it makes sense to talk to your doctor about getting tested. It is much less commonly used as the bacteria are most likely to bind to joint and nerve tissues and more difficult to detect.įor more on the Lyme testing process as defined by the CDC, check out this flow chart. Alternatively, the polymerase chain reaction (PCR) is a highly sensitive test that detects DNA from the Borrelia bacteria in fluid drawn from an infected joint (typically synovial or cerebrospinal fluid).Together these tests are known as the ELISA/Western Blot. The Western blot detects antibodies to several proteins of B. Laboratory diagnosis of Lyme disease has traditionally used a two-tier process for detecting the presence of antibodies against Borrelia burgdorferi in a patient’s blood. The western blot is usually run as a second-stage to confirm the diagnosis following a positive ELISA result. ![]() burgdorferi and, if positive, is followed up by the Western Blot test. The Enzyme-linked immunosorbent assay or ELISA is the first step.The following tests are FDA-approved for diagnosis: There is much debate over the accuracy and reliability of the laboratory tests and the likelihood of false positives and false negatives. Lyme disease is typically assessed based on clinical diagnosis, in combination with laboratory tests. What does this mean for you? By all means, if your doctor recommends a test, get the test. In other words you could have Lyme but the test results will still come up negative. The immunoblot test is also known as a Lyme Disease Line Blot test. It can take your body up to two months to develop enough antibodies to be detected by these tests. Description: Lyme Disease Western Blot Test (Labcorp) The Lyme Disease Western Blot test is typically used as a confirmatory test for people who have had positive results from previous Lyme Disease testing. Therefore a blood test at this time will often appear negative. However, with early-stage Lyme your antibodies may not have had time to develop in your body. This bacteria is called Borrelia burgdorferi, or Bb. ![]() Please direct any questions regarding coding to the payer being billed.The current laboratory diagnostic tests for Lyme disease are blood tests to detect the antibodies created by your body to fight and kill the bacteria that causes Lyme. To get a CDC reportable diagnosis of Lyme disease on a Western Blot, the sample needs to react to 5 proteins on the IgG antibody test or 2 proteins on the IgM. CPT coding is the sole responsibility of the billing party. The CPT codes provided are based on AMA guidelines and are for informational purposes only. burgdorferi antibodies may be falsely negative in early stages of Lyme disease, including the period when erythema migrans is apparent. burgdorferi blot).The screening test and/or blot for B. Positive or equivocal screening test results should not be interpreted as truly positive until verified as such using a supplemental assay (e.g., B. Immunoblot testing is appropriate for confirming a detected screening result.Īdditional Information: As recommended by the Food and Drug Administration (FDA), all samples with positive or equivocal results in a Borrelia burgdorferi antibody screen will be tested using a blot method. by the CDC, all samples which test positive or indeterminate on a serological screening test should be re-tested on a B. Methodology: Immunoassay (IA) Reflex: Immunoblot (IB)Ĭlinical Significance: Lyme Disease Antibody with Reflex to Blot (IgG, IgM) – Lyme disease is caused by a bacterium borrelia burgdorferi and is transmitted by ticks. A screening test with high sensitivity is used as the first step in the CDC recommended algorithm. Immunoblot testing qualitatively examines, with high specificity, antibodies in a patient’s specimen. Transport: Store serum at 2-8☌ after collection and ship the same day per packaging instructions included with the provided shipping box.Ĭauses for Rejection: Specimens other than serum improper labeling samples not stored properly samples older than stability limits grossly hemolyzed, grossly lipemic, or grossly icteric samples
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